AB0304 PATIENTS WITH RHEUMATOID ARTHRITIS PRESENTING WITH MONO- OR OLIGO-ARTHRITIS AND HIGH PATIENT GLOBAL ASSESSMENT REMAIN MOST FATIGUED DURING 5-YEARS FOLLOW-UP

Background The severity of fatigue in rheumatoid arthritis (RA) has hardly improved recent decades, leaving a large unmet need. Fortunately, not all RA-patients suffer from persistent fatigue, but the subgroup patients who most is insufficiently recognizable at diagnosis. As disease activity partly coupled to Disease-Activity-Score (DAS)-components may associate with course fatigue. Objectives We aimed identify remain fatigued by studying DAS-components diagnosis relation over 5-year follow-up period two independent early RA-cohorts. Methods 1560 consecutive included Leiden Early-Arthritis Cohort and 415 tREACH-Cohort were studied. Swollen Joint Count (SJC), Tender (TJC), Erytrocyte Sedimentation Rate (ESR) Patient Global Assessment (PGA) (Visual Analogue Scale(VAS),0-100mm) studied (VAS, 0-100mm) during 5-years using linear mixed models. Results Higher TJC PGA associated more severe SJC, contrast, showed an inverse association; mono- or oligo-arthritis remained fatigued. combination aforementioned characteristics revealed that presenting PGA≥50 time(+20mm versus polyarthritis PGA<50), whilst DAS-course time was different. This comprised 14% RA-population. Data tREACH-cohort similar findings. Conclusion are characterized high PGA(VAS≥50) understanding enable early-intervention non-pharmacological approaches dedicated patient groups. Figure 1. Fatigue trajectories stratified for combined DAS-characteristics Legend: Depicted mean effect sizes models scores different subgroups. subgroups based on DAS-characteristics, SJC PGA, Abbreviations: EAC, Early Arthritis Cohort; DAS, Disease Activity Score; Count; Assessment, tREACH; treatment Rotterdam Cohort. Acknowledgements N/A. Disclosure Interests None Declared.